Syracuse vs. Virginia odds, prediction, line: 2022 Week 4 college football picks by model on 51-43 run

JMA Wireless Dome showcases a conference battle on Friday evening. The Virginia Cavaliers visit the Syracuse Orange in the sixth all-time matchup between the ACC foes. Virginia is 2-1 and playing its first conference game of the 2022 season. Syracuse is 3-0, including a 1-0 mark in conference play, and the Orange are looking to stop a three-game losing skid to Virginia.

Caesars Sportsbook lists the Orange as 10-point home favorites for this 7 p.m. ET kickoff. The total number of points Vegas thinks will be scored, or the over/under, is 53.5 in the latest Syracuse vs. Virginia odds. Before making any Virginia vs. Syracuse picks, you need to see the college football predictions and betting advice from SportsLine’s advanced computer simulation model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Virginia vs. Syracuse and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model’s picks. Now, here are several college football odds and betting lines for Syracuse vs. UVA:

  • Virginia vs. Syracuse spread: Syracuse -10
  • Virginia vs. Syracuse over/under: 53.5 points 
  • Virginia vs. Syracuse money line: Syracuse -385, Virginia +300
  • VIR: The Cavaliers are 7-8 against the spread in the last 15 games 
  • SYR: The Orange are 11-4 against the spread in the last 15 games 
  • Virginia vs. Syracuse picks: See picks here

Featured Game | Syracuse Orange vs. Virginia Cavaliers

Why Virginia can cover

Virginia’s offense has sky-high upside. The Cavaliers have exceeded 500 total yards in two of three games this season, and Virginia has a strong ground attack. Virginia is averaging almost 180 rushing yards per game and 4.6 yards per carry, with quarterback Brennan Armstrong bringing a dual-threat element. Armstrong has more than 1,000 career rushing yards, and he is coming off a 2021 season in which he produced 4,449 passing yards and 31 touchdowns. 

On the outside, Virginia has an intriguing and dynamic threat in Keytaon Thompson. He caught 78 passes for 990 yards last season and has 18 catches for 235 yards in three games in 2021. Thompson also rushed for more than 230 yards on 39 carries in 2021, and he is difficult for opposing defenses to contain. Virginia is also facing a Syracuse defense that is allowing a 73.5% completion rate through three games, and the Cavaliers are well-coached and will not be overwhelmed by the road environment in Syracuse.

Why Syracuse can cover

Syracuse’s 2022 season has been impressive on both sides of the ball. The Orange are producing at a high level on offense, and Syracuse’s defense has a potentially friendly matchup on Friday. Syracuse is giving up only 16.7 points per game this season, and opponents are averaging only 98.3 rushing yards per game against the Orange. Virginia is also scuffling in a significant way when it comes to putting points on the board. 

The Cavaliers are averaging only 17.7 points per game, with only 19 points combined in the last two games. Virginia scored only three points against Illinois and 16 points against Old Dominion, and the Cavaliers produced only 222 total yards with three turnovers against Illinois. For the season, Virginia is completing only 51.9% of pass attempts with more interceptions than touchdowns. The Cavaliers are also second-worst among ACC clubs with a third down conversion rate of only 32.6% through three games.

How to make Virginia vs. Syracuse picks

SportsLine’s model is leaning Under on the point total, with both teams projected to throw at least one interception. The model also says one side of the spread hits in almost 60% of simulations. You can only see the model’s CFB picks at SportsLine.

So who wins Virginia vs. Syracuse? And which side of the spread hits in almost 60% of simulations? Visit SportsLine now to see which side of the Virginia vs. Syracuse spread you need to jump on Friday, all from the model that has crushed its college football picks, and find out.  

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