Purdue vs. Syracuse odds, prediction, line: 2022 Week 3 college football picks from model on 50-41 run


The Syracuse Orange (2-0) host the Purdue Boilermakers (1-1) in an ACC vs. Big Ten battle on Saturday afternoon. Both teams have found success offensively, scoring 30-plus in each of their first two matchups thus far this season. Last week, Syracuse smoked UConn 48-14. The Boilermakers shut out Indiana State 56-0.

Kickoff from JWA Wireless Dome in Syracuse is set for noon ET. The Orange are 1.5-point favorites in the latest Purdue vs. Syracuse odds from Caesars Sportsbook. The over/under for total points is set at 60. Before locking in any Syracuse vs. Purdue picks, be sure to check out the college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It enters Week 3 of the 2022 college football season on a 50-41 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Purdue vs. Syracuse and just revealed its picks and CFB predictions. You can visit SportsLine now to see the model’s picks. Now, here are several college football odds and trends for Syracuse vs. Purdue:

  • Purdue vs. Syracuse spread: Syracuse -1.5 
  • Purdue vs. Syracuse over/under: 60 points  
  • Purdue vs. Syracuse money line: Boilermakers +105, Orange -125
  • PUR: Boilermakers are 4-1 ATS in their last five games overall 
  • SYR: Orange are 6-1 ATS in their last seven home games 
  • Purdue vs. Syracuse picks: See picks here

Featured Game | Syracuse Orange vs. Purdue Boilermakers

Why Syracuse can cover

The Orange have a nice collective group of pass catchers to help out quarterback Garrett Shrader. Sophomore running back Sean Tucker is a soft-handed receiver coming out of the backfield. He’s first on the team in catches (10) and receiving yards (101). Senior receiver Devaughn Cooper is a deep threat weapon who can stretch the field for this offense. He’s snagged seven passes for 87 yards with 12.4 yards per reception.

Sophomore Oronde Gadsden II is looking to carve a larger role within this offense. Gadsden II is a big-boded weapon (6-foot-5) with the physicality to be a force in the red zone. The Florida native is third on the team in catches (6) and receiving yards (81). In Week 1 against Louisville, he caught three passes for 36 yards with a touchdown. 

Why Purdue can cover

Senior quarterback Aidan O’Connell had a terrific campaign last season, being named to the 2021 All-Big Ten team. O’Connell threw for 3,712 with 28 passing touchdowns. He is an athletic and accurate passer who plays in rhythm. The Illinois native has tossed 576 yards along with five scores through two games. 

Senior receiver Charlie Jones is a nice route runner who offers exceptional run after catch ability. Jones has reliable hands with the ability to snag any pass out of the air. The Illinois native knows how to track deep passes and high-point jump balls. Jones is leading the Big Ten in catches (21), receiving yards (286) and receiving touchdowns (4). He’s reeled in 130-plus yards in both games thus far. 

How to make Purdue vs. Syracuse picks

SportsLine’s model is leaning Under on the total, projecting the teams to combine for 50 points. The model also says one side of the spread hits in well over 50% of simulations. You can only get the model’s pick at SportsLine. 

So who wins Purdue vs. Syracuse? And which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out. 





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