Oklahoma vs. Nebraska odds, prediction, line: 2022 Week 3 college football picks by proven model on 50-41 run

The Oklahoma Sooners and Nebraska Cornhuskers renew one of college football’s most storied rivalries on Saturday when the two teams collide at Memorial Stadium in Lincoln, Neb. The Sooners (2-0), who are ranked No. 6 in the country, and the Cornhuskers (1-2) are meeting for the 88th time. Oklahoma leads the all-time series 46-38-3. They played 70 straight seasons (1928-’97) and were members of the Big 12 until the Huskers left for the Big Ten after the 2010 season. Saturday’s game will be the first for Nebraska since Scott Frost was fired as coach after last week’s loss to Georgia Southern. Mickey Joseph is serving as the interim head coach.

Kickoff is noon ET. The Sooners are 11-point favorites in the latest Oklahoma vs. Nebraska odds from Caesars Sportsbook, while the over/under for total points scored is 65.5. Before making any Nebraska vs. Oklahoma picks, you need to see the college football predictions and betting advice from SportsLine’s advanced computer simulation model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It enters Week 3 of the 2022 college football season on a 50-41 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Oklahoma vs. Nebraska and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model’s picks. Now, here are several college football odds and betting lines for Nebraska vs. Oklahoma: 

  • Oklahoma vs. Nebraska spread: Sooners -11
  • Oklahoma vs. Nebraska over/under: 65.5 points
  • Oklahoma vs. Nebraska money line: Sooners -420, Cornhuskers +320
  • OU: Marvin Mims Jr. leads the Big 12 in all-purpose yards per game (150.5).
  • NEB: Anthony Grant ranks third in the country in rushing yards per game (142.7).
  • Oklahoma vs. Nebraska picks: See picks at SportsLine

Featured Game | Nebraska Cornhuskers vs. Oklahoma Sooners

Why Oklahoma can cover

The defense has been solid through two games. With the defensive-minded Brent Venables in charge of the program, Oklahoma is allowing just 8.0 points per game, which ranks 10th in the country. The Sooners have allowed only one touchdown, marking the first time since 2013 they have permitted only one touchdown over any two-game span.

In addition, Oklahoma has excelled in taking care of the ball and forcing turnovers so far this season. The Sooners are one of 12 teams (and one of just five in the Power Five conferences) that hasn’t committed a turnover this season. The team’s +4 turnover margin is tied for eighth in the country.

Why Nebraska can cover

Grant has been red-hot to start the season. A junior college transfer from New Mexico Military Institute who started his career at Florida State, Grant ranks third in the country in rushing yards per game (142.7). He is the first Nebraska running back to top 100 yards in each of his first three games since Bobby Reynolds in 1950.

In addition, the Cornhuskers face an Oklahoma offense that isn’t on the field much. The Sooners rank second-to-last in the country in time of possession (22 minutes, 34 seconds per game). That bodes well for a Nebraska team that had the time of possession edge (31:56) against Georgia Southern.

How to make Nebraska vs. Oklahoma picks

SportsLine’s model is leaning Under on the total, projecting 57 combined points. The model also says one side of the spread hits in more than 50% of simulations. You can only see the model’s pick at SportsLine. 

So who wins Oklahoma vs. Nebraska? And which side of the spread hits in more than 50% of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.  

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